Hinu Rongoā Sodium Stearyl Fumarate (SSF) | Hototahi API Teitei, He Rerekē ki te Magnesium Stearate, Tohu GMP
Ko te Konutai Stearyl Fumarate (SSF) o te Tohu Rongoā
Tirohanga Whānui o te Hua
Ko te Sodium Stearyl Fumarate (SSF) he hinu whakahinuhinu rongoā mahi-teitei e mōhiotia whānuitia ana hei huarahi kē atu ki ngā hinu whakahinuhinu tuku iho pērā i te konupūmā stearate me te talc.He tote konutai o te waikawa stearyl fumaric, he paura ma ki te mā-parauri, he āhuatanga amphiphilic e āhei ai te whakahinuhinu rohe whai hua i roto i ngā whakatakotoranga papa me ngā kāpūru..
Tuakiri Hua:
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Ingoa Matū:Konutai Stearyl Fumarate
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Tau CAS:4070-80-8
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Tau Rēhita CDE:F20190000009
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Nama DMF:38822
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Te Whakatutukitanga o te Pharmacopoeia:USP-NF, EP, JP
Ngā Āhuatanga Matua me ngā Painga
1. Hototahi API Pai Rawa
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Ka whakatau i ngā raruraru hototahi e pā pinepine ana ki te konupora stearate
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Ko ngā āhuatanga kore hototahi o te API ki te konupora stearate ko: Azathioprine, Cefaclor, Cilazapril, Clopidogrel, Diclofenac, Ibuprofen, Omeprazole, me te tini ke atu.
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He pai mō ngā whakatakotoranga e āwangawanga ana mō te kore hototahitanga matū
2. Pakari ki te Whakahinuhinu Nui
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He rerekē ki te konupora stearate, ka mau tonu te mahi a te SSF ahakoa te roa o te wā whakaranu.
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Ka whakarato i te pakeketanga o te papa me te pakaru tonu, me te kore he pānga "whakahinuhinu nui rawa".
3. Ngā Āhuatanga Papa Whakarei Ake
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Te mārō nuii ngā kaha pēhanga ōrite ki ērā atu hinu whakahinuhinu
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He iti ake te pānga ki te wā pakaru– e pupuri ana i te tere o te pakaru o te papa
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Kāore he pānga kino ki te bioavailability– kia mau tonu ngā kōtaha tukunga rongoā
4. Te āhua wai-whakaaro me te āhua wairewa-haurua
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Hinu whakahinuhinu wairewa-wai – 0.5 mg/100 mL i te 25°C, ka piki ake ki te 20 g/100 mL i te 90°C
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He iti noa ngā toenga i roto i te wairewa, ā, he mea tino pai mōpapa pupuhi
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Whakapai ake i ngā kōtaha whakarewa o ngā API kore e tino wairewa
5. Ngā Āhuatanga Ā-tinana Pai Rawa