Ngā Triglycerides Mekameka-Waenga (MCT) Taumata Rongoā | Kaiwhakarewa Lipophilic me te Kaikawe Rongoā mō te Waha/Te Pānga/Te Werohanga | USP/EP/ChP

Ngā Triglycerides mekameka-waenga (MCT) o te karaehe rongoā

Tirohanga Whānui o te Hua

Ko ngā Triglycerides mekameka-waenga (MCT) he mea hanga mai i te ranunga o ngā triglycerides o ngā waikawa ngako kukū, ko te nuinga ko te waikawa caprylic (C8H16O2, waikawa octanoic) me te waikawa capric (C10H20O2, waikawa decanoic).Ka riro mai ēnei triglycerides i te hinu pūmau i tangohia mai i te wāhanga mārō, maroke o te endosperm o te kokonati (Cocos nucifera L.) i te endosperm maroke rānei o te nikau hinu (Elaeis guineensis Jacq.)Ka wehea ngā waikawa ngako mai i te hinu ngako, ā, ka whakaesterihia anō ki te glycerol hei whakaputa i te hua whakamutunga..

Tuakiri Hua:

• Ingoa Matū:Ngā Triglycerides mekameka-waenga / Triglyceride kapiririki/kapriki

• Tau CAS:73398-61-5 (me 85409-09-2, 538-24-9 rānei)

• Tau Rēhita CDE:F20220000316

• Te Whakatutukitanga o te Pharmacopoeia:ChP (CP2020), USP-NF (Ngā Triglycerides mekameka-waenga), EP (Ngā Triglycerides, mekameka-waenga), JP (Tīcarides waikawa ngako mekameka-waenga)

• Ngā kupu taurite:Hinu MCT, Caprylic/Capric Triglyceride, Glycerides whakaranu decanoyl me te octanoyl, Miglyol® 812 ōrite, Labrafac™ CC ōrite

• Āhua:Kore tae ki te wai hinuhinu he kōwhai, tata kore kakara, kāore hoki he reka.

• Te Pūwāhi Hukapapa:Tata ki te 0°C

Ngā Āhuatanga Matua me ngā Painga

1. Ngā Āhuatanga Pai o te Whakarewa

• He whakarewa pai rawa atu mō ngā rongoā lipophilic me ngā API ngoikore-wairewa

• Ka whakarei ake i te whakarewatanga me te pumau o ngā matū lipophilic

• Ka whakapai ake i te waatea o ngā rongoā Akomanga II me te Akomanga IV (whakarōpūtanga BCS)

2. Te Ngongo Tere me te Pūmua

• Ka mimiti tika ki roto i te tohanga toto, kāore e hiahiatia he tote au, he whākōkī repeure rānei.

• Ka tere te whakapūngao hei whakarato i te pūngao tere

• Te tere ake o te tukunga o te API ki te tohanga ā-tinana, ka pai ake pea te tīmatanga o te mahi

3. Kōtaha Pūmautanga Pai rawa atu

• Te ātete nui ki te waikura (uara iodine ≤1.0)

• He iti te pāngia e te ahotea wera me te ahotea waikura

• Ka pupuri i te pumau me te roa o te wā e rongoa ai ngā rongoā

• Pūmau ki ngā pāmahana rokiroki whānui (≤25°C te tūtohu)

4. Ngā Āhuatanga Ā-tinana Pai Rawa

• Te matotoru:~30 mPa·s i te 20°C (he iti te matotoru mō te ngāwari o te whakahaere)

• Taumaha Motuhake:0.93-0.96 i te 20°C

• Taupū Whakaata:1.440-1.452 i te 20°C

• He iti te matotoru e tika ana mō ngā momo horopeta wai me ngā momo horopeta haurua-totoka

5. Hototahi Pai rawa atu

• Hototahi ki te whānuitanga o ngā API me ngā matū rongoā

• Ka taea te whakauru ngāwari ki roto i ngā momo whakatakotoranga me te kore he raruraru hototahi

• He kakara me te reka kūpapa – he mea pai mō ngā whakaritenga ā-waha ina nui te reka

6. Kōtaha Whakahaere me te Haumaru

• Tūnga GRAS (E mōhiotia whānuitia ana he Haumaru)

• Kāore he paitini, kāore e whakapataritari i te kiri me ngā kanohi

• LD50 (kiore, waha): 29.6 karamu/kg – tino haumaru

• I hangaia te GMP me te mana whakahaere kounga tino pakari

• Kua rēhitatia te CDE (F20220000316) mō te mākete Haina

• Kei te wātea me te tautoko ture mō ngā tukunga ā-ao